UK-Doctoral Studentships in Chemical Biology

Chemical Biology Centre, UK

Several EPSRC Doctoral Training Centre Studentships are available for a range of projects within the Chemical Biology Centre (CBC). The value of award will be £15,000 (tax free p.a).

The Chemical Biology Centre (CBC) is a joint venture between Imperial College, the Institute of Cancer Research (ICR) and London Research Institute of Cancer Research UK (CRUK). The CBC has been awarded an EPSRC (Engineering and Physical Sciences Research Council) Doctoral Training Centre (DTC) in the area of Chemical Biology.

The CBC has particular expertise and interest in working on the molecular details of protein and lipid interaction and its subsequent application to the development of biomolecular therapies. There will be particular emphasis on quantitative measurement and modelling, focussing on the study of macromolecular interactions, in particular where intervention may lead to further understanding of diseases and be ultimately of clinical benefit.

The CBC focuses on the training of physical scientists in the arts of multidisciplinary chemical biology research. The training programme provides a means whereby young physical scientists can bridge disparate fields and gain the confidence to grapple with biomolecular research in a multidisciplinary environment.

Currently the CBC has the following fully funded studentships available, commencing in October 2008:

1. Single Molecule Studies on the Allosteric Behaviour of a Protein Folding Nanomachine
2. N-myristoyl Transferase in Apoptosis and Disease: A Novel Target for Cancer Therapy
3. Biophysical Requirements for Zipper-like Phagocytosis
4. An Integrated Theoretical and Experimental Platform for Probing Protein-Protein Interactions (PPIs)
5. Modelling Mutant Receptor-Ligand Analogue Pairs to Predict Unique Phosphoinositide-Protein Interactions
6. Fragment Tethering for the Development of Small Molecule Inhibitors of Protein-Protein Interactions
7. Bridging the In-vivo In-Vitro Divide in Non-Specific Binding
8. Substrate-Directed Synthesis of Chemical Receptors for Phosphatidlyinositol Phosphates to Moderate Lipid-Protein Interaction.
9. How does alpha toxin break down the membrane?
10. Single Molecule Measurements of the Catalytic Events in Proteolysis
11. FRET Analysis of Interactions of the Macromolecular Complex AMPK, a Regulator of Cellular Metabolism.
12. High throughput FRET of molecular interactions during HIV assembly and budding

Application Deadline: 31 March 2008

For further information on these studentships and details on how to apply, please visit: http://www.chemicalbiology.ac.uk/studentships.html